9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro
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منابع مشابه
9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro.
Retinoic acid exhibits effects on the proliferation and differentiation of many hematopoietic cells. Cellular responsiveness to retinoic acid (RA) is conferred through two distinct classes of nuclear receptors, the RA receptors (RARs) and the retinoid X receptors (RXRs). The RARs bind to both 9-cis- and all-trans-RAs, but 9-cis-RA alone directly binds and activates RXR. This suggested that 9-ci...
متن کاملEffects of Novel Retinoic Acid Compound, 9-cis-Retinoic Acid, on Proliferation, Differentiation, and Expression of Retinoic Acid Receptor-a
Retinoic acid modulates proliferation and differentiation of a wide variety of normal and leukemic cells through two distinct families of transcriptional factors: the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). A stereoisomer of retinoic acid, 9-cis-retinoic acid, is a highaffinity ligand for RXR and binds efficiently to RAR. In contrast, all-trans-retinoic acid interact...
متن کاملPharmacokinetics of 9-cis-retinoic acid in the rhesus monkey.
9-cis-Retinoic acid is a naturally occurring biologically active retinoid capable of binding and transactivating both the retinoic acid receptors and the retinoid X receptors. A study was performed to characterize the pharmacokinetics 9-cis-retinoic acid following i.v. bolus administration in the nonhuman primate. Groups of three animals received i.v. bolus doses of 9-cis-retinoic acid of eithe...
متن کامل9-cis retinoic acid signaling: changing partners causes some excitement.
Reports on the role of retinoids in cell metabolism can be traced back almost a century, when the then-unknown vitamin A present in dietary lipids was found to be essential for normal growth {McCollum and Davis 1913; Osborne and Mendel 1913}. Since then, the profound effect of retinoic acid IRA}, a derivative of vitamin A, on development and differentiation has been documented in numerous publi...
متن کاملIsomerization of all-trans-retinoic acid to 9-cis-retinoic acid.
The discovery of the biological activity of 9-cis-retinoic acid raises questions as to its mode of biosynthesis. A simple mechanism involves the direct isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. It is shown here that bovine liver membranes, but not supernatant fractions, can isomerize all-trans-retinoic acid into 9-cis-retinoic acid and 13-cis-retinoic acid. The concentrat...
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ژورنال
عنوان ژورنال: Blood
سال: 1993
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v81.4.1009.1009